Name : Biotinylated Human NKp46/NCR1/CD335 Protein (Primary Amine Labeling)
Product Source :
Recombinant Biotinylated Human NKp46/NCR1/CD335 Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the N-Terminus. It contains Gln22-Asn254.[Accession | AAH64806.1]
Molecular Weight :
The protein has a predicted MW of 27.5 kDa. Due to glycosylation, the protein migrates to 38-48 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Biotinylated Human NKp46 (Primary Amine Labeling) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. ELISA Data Immobilized Anti-Nkp46 Antibody, hFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human NKp46, His Tag with the EC50 of 3.1ng/ml determined by ELISA.
Background :
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.
Synonyms :
CD335; Ly94; NCR1; NKp46; MAR-1; NKP46FLJ99094
References & Citations :
(1)Glasner A, Isaacson B, Viukov S, et al. Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression.[J]. Sci Rep, 2017, 7(1):13090.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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