Name : Canine PKA/PRKACA Protein
Product Source :
Recombinant Canine PKA/PRKACA Protein is expressed from E.coli with His tag at the N-Terminus. It contains Gly2-Phe350.[Accession | NP_001003032.1]
Molecular Weight :
The protein has a predicted MW of 41.51 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by SEC-HPLC
Formulation :
Supplied as 0.22μm filtered solution in PBS, 200mM NaCl (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Canine PKA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Canine PKA is greater than 95% as determined by SEC-HPLC.
Background :
The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide variety of cellular processes including metabolism, cell growth, gene expression and apoptosis. cAMP-dependent PKA signaling pathways play important roles during infection and virulence of various pathogens. Since fluxes in cAMP are involved in multiple intracellular functions, a variety of different pathological infectious processes can be affected by PKA signaling pathways.
Synonyms :
PRKACA; PKA C-alpha; PKACA; PKA C alpha; PPNAD4
References & Citations :
Haidar M, Ramdani G, Kennedy EJ, Langsley G. PKA and Apicomplexan Parasite Diseases. Horm Metab Res. 2017 Apr;49(4):296-300. doi: 10.1055/s-0042-118459. Epub 2016 Nov 11. PMID: 27835919; PMCID: PMC5614466.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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