Name : Human PLA2G7 Protein
Product Source :
Recombinant Human PLA2G7 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Phe22-Asn441.[Accession | Q13093]
Molecular Weight :
The protein has a predicted MW of 48.9 kDa. Due to glycosylation, the protein migrates to 49-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in 50mM NaAc, 150mM NaCl, 10% Glycerol (pH 5.0).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human PLA2G7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Endogenous PLA2G7 transcription levels were found to be significantly lower in vascular related cell lines than in the other cell lines. Luciferase reporter gene assays indicated that gene activity was significantly enhanced by PLA2G7 promoter fragment. LA2G7 transcription was found to be up-regulated with the treatment of DAC. The 17-β-estradiol was found to down-regulate PLA2G7 transcription in all the cell lines.
Synonyms :
LDL-PLA2; PAFAD; PAFAH
References & Citations :
(1) Jiang D, Wang Y, Shen Y, Xu Y, Zhu H, Wang J, Wang H, Duan S. Estrogen and promoter methylation in the regulation of PLA2G7 transcription. Gene. 2016 Oct 10;591(1):262-267. doi: 10.1016/j.gene.2016.07.048. Epub 2016 Jul 21. PMID: 27450918.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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