Name : Canine PRLR Protein
Product Source :
Recombinant Canine PRLR Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Gln25-Thr235.[Accession | XM_038663941.1]
Molecular Weight :
The protein has a predicted MW of 53.89 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Canine PRLR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Canine PRLR is greater than 95% as determined by SEC-HPLC.
Background :
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers.
Synonyms :
PRL-R; HPRL; MFAB; Prolactin R
References & Citations :
(1) Zhou Y, Zong H, Han L, Xie Y, Jiang H, Gilly J, Zhang B, Lu H, Chen J, Sun R, Pan Z, Zhu J. A novel bispecific antibody targeting CD3 and Prolactin receptor (PRLR) against PRLR-expression breast cancer. J Exp Clin Cancer Res. 2020 May 12;39(1):87. doi: 10.1186/s13046-020-01564-4. PMID: 32398042; PMCID: PMC7216678.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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