Name : Human PRAK Protein
Product Source :
Recombinant Human PRAK Protein is expressed from Baculovirus-Insect Cells with Strep-II tag at the C-terminus. It contains Met1-Gln471.[Accession | NP_003659.2]
Molecular Weight :
The protein has a predicted MW of 55.57 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 90% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in 20mM Tris, 150mM NaCl, 2mM CaCl2 (pH 8.0).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human PRAK on Tris-Bis PAGE under reduced condition. The purity is greater than 90%. SEC-HPLC The purity of Human PRAK is greater than 95% as determined by SEC-HPLC.
Background :
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-activated protein kinase activated protein kinase 5 [MAPKAPK5]) functions downstream of p38alpha and p38beta in mediating the signaling of the p38 pathway.
Synonyms :
MAPKAPK5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5
References & Citations :
New L, Jiang Y, Han J. Regulation of PRAK subcellular location by p38 MAP kinases. Mol Biol Cell. 2003 Jun;14(6):2603-16. doi: 10.1091/mbc.e02-08-0538. Epub 2003 Mar 20. PMID: 12808055; PMCID: PMC194907.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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