Name : Human PRL-2/PTP4A2 Protein
Product Source :
Recombinant Human PRL-2/PTP4A2 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Met1-Cys164.[Accession | Q12974-1]
Molecular Weight :
The protein has a predicted MW of 19.89 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in 20mM Tris, 250mM NaCl, 1mM DTT, 20% Glycerol (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human PRL-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human PRL-2 is greater than 95% as determined by SEC-HPLC. Bioactivity Data Measured by its ability to cleave a substrate. p-Nitrophenvl phosphate (pNPP). The specific activity is > 0.5 pmol/min/μg.
Background :
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators.PRL-2 is a member of PTP family and has an important function in controlling cell growth.
Synonyms :
PRL-2; PRL 2; PRL2; HU-PP-1; OV-1; OV 1; PTP(CAAXII); PTP4A2; PTPCAAX2; BM-008; BM008; HH13; HH7-2; HMT;
References & Citations :
(1) Hardy S, Kostantin E, Wang SJ, Hristova T, Galicia-Vázquez G, Baranov PV, Pelletier J, Tremblay ML. Magnesium-sensitive upstream ORF controls PRL Phosphatase expression to mediate energy metabolism. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2925-2934. doi: 10.1073/pnas.1815361116. Epub 2019 Feb 4. PMID: 30718434; PMCID: PMC6386685.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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