Name : Human PS20 Protein
Product Source :
Recombinant Human PS20 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Lys32-Gln220.[Accession | Q9HC57]
Molecular Weight :
The protein has a predicted MW of 22 kDa. The protein migrates to 25-30 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in 20mM PB, 500mM NaCl, 200mM L-arginine (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human PS20 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory infection in mice. Using ps20 knockout mice we provide evidence that intranasal MHV-1 infection results in increased lung viral titers in ps20(-/-) compared to ps20(/) mice. Roles for ps20 in regulating expression of neutrophil-specific chemotactic factors, thereby potentially modulating neutrophil migration, and in modulating neutrophil susceptibility to MHV-1 infection.
Synonyms :
Ps20; Wfdc1
References & Citations :
(1) Rogers E, Wang BX, Cui Z, Rowley DR, Ressler SJ, Vyakarnam A, Fish EN. WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection. Antiviral Res. 2012 Nov;96(2):158-68. doi: 10.1016/j.antiviral.2012.08.012. Epub 2012 Sep 6. PMID: 22960155; PMCID: PMC7114264.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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