Name : Human PLVAP Protein
Product Source :
Recombinant Human PLVAP Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Tyr49-Gly442.[Accession | Q9BX97]
Molecular Weight :
The protein has a predicted MW of 45.97 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human PLVAP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases.
Synonyms :
FELS; PV1
References & Citations :
Nakagami Y, Hatano E, Chayama Y, Inoue T. An anti-PLVAP antibody suppresses laser-induced choroidal neovascularization in monkeys. Eur J Pharmacol. 2019 Jul 5;854:240-246. doi: 10.1016/j.ejphar.2019.04.035. Epub 2019 Apr 23. PMID: 31026444.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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