Name : Human Serpin F1/PEDF Protein
Product Source :
Recombinant Human Serpin F1/PEDF Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gln20-Pro418.[Accession | P36955]
Molecular Weight :
The protein has a predicted MW of 45.5 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in 20mM Tris, 500mM NaCl (pH 8.0).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Serpin F1/PEDF on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human Serpin F1/PEDF is greater than 95% as determined by SEC-HPLC.
Background :
Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis.
Synonyms :
PEDF; EPC-1; Serpin F1; SERPINF1; PIG35
References & Citations :
(1) Ansari D, Althini C, Ohlsson H, Bauden M, Andersson R. The Role of PEDF in Pancreatic Cancer. Anticancer Res. 2019 Jul;39(7):3311-3315. doi: 10.21873/anticanres.13473. PMID: 31262851.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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