Name : Mouse SG3/Secretogranin 3 Protein
Product Source :
Recombinant Mouse SG3/Secretogranin 3 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Phe23-Leu471.[Accession | P47867]
Molecular Weight :
The protein has a predicted MW of 52 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse SG3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse SG3 is greater than 95% as determined by SEC-HPLC.
Background :
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regulation. Unlike many other known angiogenic factors, the pro-angiogenic actions of Scg3 are restricted to pathological conditions. Among thousands of quantified endothelial ligands, Scg3 has the highest binding activity ratio to diabetic vs.
Synonyms :
Secretogranin-3; Secretogranin III; SCG3; SGIII; UNQ2502/PRO5990
References & Citations :
(1) Li W, Webster KA, LeBlanc ME, Tian H. Secretogranin III: a diabetic retinopathy-selective angiogenic factor. Cell Mol Life Sci. 2018 Feb;75(4):635-647. doi: 10.1007/s00018-017-2635-5. Epub 2017 Aug 30. PMID: 28856381; PMCID: PMC5771826.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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