Name : FITC-Labeled Human Siglec-2/CD22 Protein
Product Source :
Recombinant FITC-Labeled Human Siglec-2/CD22 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Asp20-Arg687.[Accession | P20273-1]
Molecular Weight :
The protein has a predicted MW of 101.9 kDa. Due to glycosylation, the protein migrates to 130-140 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE FITC-Labeled Human Siglec-2/CD22 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer’s patches in mice.
Synonyms :
CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814
References & Citations :
(1)Kato J , Robert T. O’Donnell, Abuhay M , et al. Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin’s lymphoma[J]. OncoImmunology, 2012, 1(9):7.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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