Name : Mouse Siglec-15/CD33L3 Protein
Product Source :
Recombinant Mouse Siglec-15/CD33L3 Protein is expressed from HEK293 with His and Avi tag at the C-Terminus. It contains Arg24-Thr262.[Accession | A7E1W8-1]
Molecular Weight :
The protein has a predicted MW of 26.7 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in 20mM PB, 0.5M NaCl, 0.1M L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse Siglec-15 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
Synonyms :
CD33 molecule-like 3; CD33L3; HsT1361; Siglec15; CD33 antigen-like 3; SIGLEC-15
References & Citations :
(1)Jun Wang,et al.Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.Nature Medicine (2019).
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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