Name : Biotinylated Human SLAMF1/SLAM/CD150 Protein
Product Source :
Recombinant Biotinylated Human SLAMF1/SLAM/CD150 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Ala21-Pro237.[Accession | Q13291-1]
Molecular Weight :
The protein has a predicted MW of 27.2 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Biotinylated Human SLAMF1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Biotinylated Human SLAMF1 is greater than 95% as determined by SEC-HPLC.
Background :
SLAMF1/CD150 receptor is a founder of signaling lymphocyte activation molecule (SLAM) family of cell-surface receptors. It is widely expressed on cells within hematopoietic system. In hematologic malignancies CD150 cell surface expression is restricted to cutaneous T-cell lymphomas, few types of B-cell non-Hodgkin’s lymphoma, near half of cases of chronic lymphocytic leukemia, Hodgkin’s lymphoma, and multiple myeloma.
Synonyms :
CDw150; IPO-3; CD150; SLAMF1; SLAM
References & Citations :
(1)Gordiienko I, Shlapatska L, Kovalevska L, Sidorenko SP. SLAMF1/CD150 in hematologic malignancies: Silent marker or active player? Clin Immunol. 2019 Jul;204:14-22. doi: 10.1016/j.clim.2018.10.015. Epub 2018 Oct 25. PMID: 30616923.
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