Name : Human UBASH3B/STS1 Protein

Product Source :
Recombinant Human UBASH3B/STS1 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Gly380-Glu649.[Accession | Q8TF42]

Molecular Weight :
The protein has a predicted MW of 31.88 kDa same as Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human UBASH3B on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human UBASH3B is greater than 95% as determined by SEC-HPLC.

Background :
UBASH3/STS/TULA is a novel two-member family, which exerts several key regulatory effects in multiple cell types. UBASH3B/STS-1/TULA-2 is a highly active protein tyrosine phosphatase; its major target appears to be a specific regulatory site of protein tyrosine kinases of the Syk family, dephosphorylation of which inhibits Syk and Zap-70 kinases and suppresses receptor signaling mediated by these kinases.

Synonyms :
STS-1; UBASH3B; TULA-2; TULA 2; TULA2; KIAA1959; p70;

References & Citations :
Tsygankov AY. TULA-family proteins: Jacks of many trades and then some. J Cell Physiol. 2018 Jan;234(1):274-288. doi: 10.1002/jcp.26890. Epub 2018 Aug 4. PMID: 30076707.

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