Name : Mouse Syndecan-1 Protein

Product Source :
Recombinant Mouse Syndecan-1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Gln23-Gly255.[Accession | P18828-1]

Molecular Weight :
The protein has a predicted MW of 51 kDa. Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 90% as determined by Tris-Bis PAGE> 90% as determined by HPLC

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Mouse Syndecan-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%. SEC-HPLC The purity of Mouse Syndecan-1 is greater than 90% as determined by SEC-HPLC.

Background :
Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver.

Synonyms :
Syndecan-1; SYND1; CD138; SDC1; SDC; SDC1

References & Citations :
(1)Regős E, Karászi K, Reszegi A, Kiss A, Schaff Z, Baghy K, Kovalszky I. Syndecan-1 in Liver Diseases. Pathol Oncol Res. 2020 Apr;26(2):813-819. doi: 10.1007/s12253-019-00617-0. Epub 2019 Mar 2. PMID: 30826971; PMCID: PMC7242248.

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