Name : Human TACI/TNFRSF13B Protein
Product Source :
Recombinant Human TACI/TNFRSF13B Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Ser2-Thr166.[Accession | O14836-1]
Molecular Weight :
The protein has a predicted MW of 45.3 kDa. Due to glycosylation, the protein migrates to 38-40 kDa and 50-55 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human TACI on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human TACI is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human BAFF Trimer, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human TACI, hFc Tag with the EC50 of 3.0ng/ml determined by ELISA.
Background :
Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL). TACI is a regulator in the immune responses. TACI inhibits B cell expansion and promotes the differentiation and survival of plasma cells.
Synonyms :
CD267; TNFRSF13B; TACI; CVID; CVID2; IGAD2; RYZN; TACI
References & Citations :
(1) Zhang Y, Li J, Zhang YM, Zhang XM, Tao J. Effect of TACI signaling on humoral immunity and autoimmune diseases. J Immunol Res. 2015;2015:247426. doi: 10.1155/2015/247426. Epub 2015 Mar 17. PMID: 25866827; PMCID: PMC4381970.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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