Name : Human TGM3/Transglutaminase 3 Protein
Product Source :
Recombinant Human TGM3/Transglutaminase 3 Protein is expressed from Baculovirus-Insect Cells with His tag at the N-terminus. It contains Ala2-Glu693.[Accession | Q08188]
Molecular Weight :
The protein has a predicted MW of 78.23 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 10% Glycerol (pH 8.5).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human TGM3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human TGM3 is greater than 95% as determined by SEC-HPLC. Bioactivity Data Measured by its ability to cleave a synthetic peptide Benzvloxvcarbonvl-GIn-Glvand NH2OH.The specific activity is > 450 pmol/min/ug, as measured under the described conditions.
Background :
TGM3, encoded by the TGM3 gene, is widely expressed in the small intestine, brain, skin and mucosa. In the skin and mucosa, TGM3 is predominantly expressed in the suprabasal layers of the stratified squamous epithelium. It has been demonstrated that TGM3 is essential for epidermal terminal differentiation and formation of the cornified cell envelope through cross-linking structural proteins such as involucrin, loricrin and small proline-rich proteins.
Synonyms :
TG(E); TGE; TGase E; TGase-3; Transglutaminase 3; TGM3
References & Citations :
Wu X, Cao W, Wang X, Zhang J, Lv Z, Qin X, Wu Y, Chen W. TGM3, a candidate tumor suppressor gene, contributes to human head and neck cancer. Mol Cancer. 2013 Dec 1;12(1):151. doi: 10.1186/1476-4598-12-151. PMID: 24289313; PMCID: PMC4176127.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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