Name : Mouse TLT-1/TREML1 Protein
Product Source :
Recombinant Mouse TLT-1/TREML1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Asp21-Gln175.[Accession | AAL85488.1]
Molecular Weight :
The protein has a predicted MW of 43.61 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse TLT-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse TLT-1 is greater than 95% as determined by SEC-HPLC.
Background :
Triggering receptor expressed on myeloid cells (TREM)-like transcript-1 (TLT-1) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-baring TREM family protein. Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) is a membrane protein receptor found in alpha-granules of platelets and megakaryocytes.
Synonyms :
TLT-1; TREML1; TLT1; Trem-like transcript 1; UNQ1825/PRO3438; dJ238O23.3; GLTL1825; MGC119173; PRO3438
References & Citations :
(1) Yoon SH, Lee YD, Ha J, Lee Y, Kim HH. TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis. J Biol Chem. 2012 Aug 24;287(35):29620-6. doi: 10.1074/jbc.M112.351239. Epub 2012 Jul 3. PMID: 22761415; PMCID: PMC3436187.(2) Morales J, Villa K, Gattis J, Castro W, Colon K, Lubkowski J, Sanabria P, Hunter R, Washington AV. Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization. Blood Coagul Fibrinolysis. 2010 Apr;21(3):229-36. doi: 10.1097/MBC.0b013e3283358116. PMID: 20093931; PMCID: PMC2886849.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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