Name : Mouse TNFRSF12A/TWEAKR Protein
Product Source :
Recombinant Mouse TNFRSF12A/TWEAKR Protein is expressed from HEK293 with hFc tag at the N-Terminus. It contains Glu28-Per80.[Accession | Q9CR75]
Molecular Weight :
The protein has a predicted MW of 32.8 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse TNFRSF12A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SPR Data Human TNFSF12, hFc Tag immobilized on CM5 Chip can bind Mouse TNFRSF12A, hFc Tag with an affinity constant of 0.15 nM as determined in SPR assay (Biacore T200).
Background :
Thyroid cancer (TC) is the most well-known endocrine neoplasia as well as a common malignant tumor in the head and neck.TNFRSF12A expression may be a potential useful prognostic molecular biomarker of bad survival in thyroid cancer, in addition, PPAR signaling pathway, insulin signaling pathway, mTOR signaling pathway may be the key pathway controlled by TNFRSF12A in thyroid cancer. Further experimental ought to be performed to demonstrate the biologic effect of TNFRSF12A.
Synonyms :
FGF-inducible 14; Fgfrp2; TNFRSF12A; FN14; CD266; TWEAKR
References & Citations :
(1) Wu ZH, Niu X, Wu GH, Cheng Q. Decreased expression of TNFRSF12A in thyroid gland cancer predicts poor prognosis: A study based on TCGA data. Medicine (Baltimore). 2020 Aug 21;99(34):e21882. doi: 10.1097/MD.0000000000021882. PMID: 32846846; PMCID: PMC7447363.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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