Name : Mouse TRAIL/TNFRSF10 Protein
Product Source :
Recombinant Mouse TRAIL/TNFRSF10 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Pro118-Asn291.[Accession | P50592]
Molecular Weight :
The protein has a predicted MW of 30.6 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in 0.1M Glycine, 150mM NaCl, 10% Glycerol (pH 3.0).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse TRAIL on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SPR Data Human TRAIL R1, hFc Tag captured on CM5 Chip via Protein A can bind Mouse TRAIL, His Tag with an affinity constant of 0.62 μM as determined in SPR assay (Biacore T200).
Background :
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.
Synonyms :
Apo-2L; TRAIL; CD253; TNFSF10; Apo-2 ligand; APO2L; TL2
References & Citations :
(1) Yuan X, Gajan A, Chu Q, Xiong H, Wu K, Wu GS. Developing TRAIL/TRAIL death receptor-based cancer therapies. Cancer Metastasis Rev. 2018 Dec;37(4):733-748. doi: 10.1007/s10555-018-9728-y. PMID: 29541897; PMCID: PMC6138568.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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