Name : Cynomolgus TYRO3 Protein
Product Source :
Recombinant Cynomolgus TYRO3 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gly41-Ser427.[Accession | A0A2K5WCY8]
Molecular Weight :
The protein has a predicted MW of 42.47 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by SEC-HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus TYRO3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Cynomolgus TYRO3 is greater than 95% as determined by SEC-HPLC.
Background :
The TAM receptors (TYRO3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the “eat-me” signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
Synonyms :
BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse
References & Citations :
(1) Myers KV, Amend SR, Pienta KJ. Targeting TYRO3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment. Mol Cancer. 2019 May 14;18(1):94. doi: 10.1186/s12943-019-1022-2. PMID: 31088471; PMCID: PMC6515593.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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