Name : Mouse TYRO3 Protein
Product Source :
Recombinant Mouse TYRO3 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Arg31-Asp419.[Accession | P55144-2]
Molecular Weight :
The protein has a predicted MW of 43 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse TYRO3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse TYRO3 is greater than 95% as determined by SEC-HPLC.
Background :
The TAM receptors (TYRO3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the “eat-me” signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
Synonyms :
BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse
References & Citations :
(1) Myers KV, Amend SR, Pienta KJ. Targeting TYRO3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment. Mol Cancer. 2019 May 14;18(1):94. doi: 10.1186/s12943-019-1022-2. PMID: 31088471; PMCID: PMC6515593.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
JAM-A Proteincustom synthesis
CD59 ProteinMolecular Weight
Popular categories:
Checkpoint Kinase 2 (Chk2)
IL-10 Receptor