Name : Human VIPR2 Protein
Product Source :
Recombinant Human VIPR2 Protein is expressed from HEK293 with mFc tag at the C-terminus. It contains Glu24-Val126.[Accession | P41587-1]
Molecular Weight :
The protein has a predicted MW of 37.35 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human VIPR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human VIPR2 is greater than 95% as determined by SEC-HPLC.
Background :
Effects of vasoactive intestinal peptide (VIP) on T cell migration are mediated by structurally distinct types I (VIPR1) and II (VIPR2) G protein-associated receptors. The two receptor types were proposed to transduce opposite effects on human T cells, since cytokine-induced chemotaxis of VIPR1-bearing HuT 78 human T cells, in contrast to T cells that express VIPR2, was inhibited by VIP.
Synonyms :
VIP-R-2; VPAC2; PACAP-R-3; PACAP-R3; VIPR2; VIP2R
References & Citations :
Schratzberger P, Geiseler A, Dunzendorfer S, Reinisch N, Kähler CM, Wiedermann CJ. Similar involvement of VIP receptor type I and type II in lymphocyte chemotaxis. J Neuroimmunol. 1998 Jul 1;87(1-2):73-81. doi: 10.1016/s0165-5728(98)00043-5. PMID: 9670847.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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