Name : Mouse VNN1 Protein
Product Source :
Recombinant Mouse VNN1 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Leu24-Asn488.[Accession | Q9Z0K8]
Molecular Weight :
The protein has a predicted MW of 53.14 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse VNN1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse VNN1 is greater than 95% as determined by SEC-HPLC.
Background :
Vanin-1 (VNN1) is anchored to the cellular membrane with pantetheinase activity, which hydrolyzes pantetheine to produce cysteamine. VNN1 can promote oxidative stress and the inflammatory response. Additionally, VNN1 has been confirmed to be overexpressed in cancer tissues of patients with PCAD and can be used as a blood biomarker for the discrimination of PCAD from type 2 diabetes.
Synonyms :
Vanin-1; Vanin 1; V-1
References & Citations :
Qin W, Kang M, Li C, Zheng W, Guo Q. VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing β‑cell dedifferentiation. Oncol Rep. 2023 Jun;49(6):120. doi: 10.3892/or.2023.8557. Epub 2023 Apr 28. PMID: 37114564; PMCID: PMC10173380.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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