Name : Cynomolgus BSPII Protein
Product Source :
Recombinant Cynomolgus BSPII Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Phe17-Gln318.[Accession | A0A2K5UM27]
Molecular Weight :
The protein has a predicted MW of 34.63 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus BSPII on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Cynomolgus BSPII is greater than 95% as determined by SEC-HPLC.
Background :
IBSP (Integrin Binding Sialoprotein) is a Protein Coding gene. Diseases associated with IBSP include Fibrous Dysplasia and Chondromalacia. Among its related pathways are Degradation of the extracellular matrix and Cytoskeletal Signaling.The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts.
Synonyms :
BNSP; BSP 2; BSP II; BSP; BSP-II; IBSP; SP II; SPII; SP-II
References & Citations :
(1) Benz F, Bogen A, Praktiknjo M, Jansen C, Meyer C, Wree A, Demir M, Loosen S, Vucur M, Schierwagen R, Tacke F, Trebicka J, Roderburg C. Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis. PLoS One. 2020 Apr 17;15(4):e0231701. doi: 10.1371/journal.pone.0231701. PMID: 32302330; PMCID: PMC7164617.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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