Name : Human CCL11 Protein
Product Source :
Recombinant Human CCL11 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Gly24-Pro97.[Accession | P51671]
Molecular Weight :
The protein has a predicted MW of 9.46 kDa. The protein migrates to 13-15 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 90% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in 20mM PB, 500mM NaCl, 200mM L-arginine (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CCL11 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CCL11 is greater than 90% as determined by SEC-HPLC.
Background :
The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases. CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate-mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders.
Synonyms :
Eotaxin; C-C motif chemokine 11; Small-inducible cytokine A11; SCYA11; eotaxin-1
References & Citations :
Parajuli B, Horiuchi H, Mizuno T, Takeuchi H, Suzumura A. CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia. Glia. 2015 Dec;63(12):2274-84. doi: 10.1002/glia.22892. Epub 2015 Jul 17. PMID: 26184677.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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