Name : Human CCL20 Protein
Product Source :
Recombinant Human CCL20 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Ala27-Met96.[Accession | P78556-1]
Molecular Weight :
The protein has a predicted MW of 9.3 kDa. The protein migrates to 12-14 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CCL20 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Recent evidence suggests that CC chemokine ligand 20 (CCL20) is upregulated after subarachnoid hemorrhage (SAH). CCL20 is upregulated in an SAH mouse model and in cultured primary microglia and neurons. CCL20-neutralizing antibody alleviated SAH-induced neurological deficits, decreased brain water content and neuronal apoptosis, and repressed microglial activation.
Synonyms :
C-C motif chemokine 20; MIP-3-alpha; LARC; MIP3A; SCYA20; CKb4; Exodus; MIP-3a; ST38; exodus-1; MIP3 alpha
References & Citations :
(1)Liao LS, Zhang MW, Gu YJ, Sun XC. Targeting CCL20 inhibits subarachnoid hemorrhage-related neuroinflammation in mice. Aging (Albany NY). 2020 Jun 21;12(14):14849-14862. doi: 10.18632/aging.103548. Epub 2020 Jun 21. PMID: 32575072; PMCID: PMC7425437.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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