Name : Human CCL7/MCP3 Protein
Product Source :
Recombinant Human CCL7/MCP3 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Gln24-Leu99.[Accession | P80098]
Molecular Weight :
The protein has a predicted MW of 10.05 kDa. The protein migrates to 14-17 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CCL7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CCL7 is greater than 95% as determined by SEC-HPLC.
Background :
Chemokine C-C motif ligand 7 (CCL7), a member of CC chemokine subfamily, is known to promote the recruitment of many innate immune cell types including monocytes and neutrophils to sites of bacterial and viral infection and eosinophils and basophils to sites of allergic inflammation. CCL7 upregulation has been associated with many inflammatory settings including infection, cardiovascular disease, and the tumor microenvironment.
Synonyms :
C-C motif chemokine 7; CCL7; NC28; MCP-3; MCP3; SCYA6; SCYA7; FIC; MARC
References & Citations :
(1) Ford J, Hughson A, Lim K, Bardina SV, Lu W, Charo IF, Lim JK, Fowell DJ. CCL7 Is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection. Front Immunol. 2019 Jan 8;9:3063. doi: 10.3389/fimmu.2018.03063. PMID: 30671055; PMCID: PMC6331479.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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