Name : Cynomolgus AFP Protein
Product Source :
Recombinant Cynomolgus AFP Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Arg19-Val609.[Accession | A0A2K5U7U0]
Molecular Weight :
The protein has a predicted MW of 67.53 kDa. Due to glycosylation, the protein migrates to 68-75 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus AFP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Cynomolgus AFP is greater than 95% as determined by SEC-HPLC.
Background :
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases.
Synonyms :
Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-feto; HPAFP; AFPD; FETA
References & Citations :
(1) Pak VN. The use of alpha-fetoprotein for the treatment of autoimmune diseases and cancer. Ther Deliv. 2018 Jan;9(1):37-46. doi: 10.4155/tde-2017-0073. PMID: 29216804.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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