Name : Mouse CD180 Protein
Product Source :
Recombinant Mouse CD180 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Thr21-Ser626.[Accession | Q62192]
Molecular Weight :
The protein has a predicted MW of 69.1 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse CD180 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse CD180 is greater than 95% as determined by SEC-HPLC.
Background :
CD180, a related member of the Toll-like receptor family, is lost or underexpressed at the plasma membrane in circulating cells of various B-cell lymphomas except marginal zone lymphomas (MZL).CD180 can be considered as a single positive robust marker of MZL and should be therefore included in flow cytometry panels for the diagnosis of mature B-cell neoplasms.
Synonyms :
CD180 antigen;Lymphocyte antigen 78;Ly-78;CD180;Rp105;LY64
References & Citations :
(1) Mayeur-Rousse C, Guy J, Miguet L, Bouyer S, Geneviève F, Robillard N, Solly F, Maar A, Bené MC, Mauvieux L; GEIL (Groupe d’Etude Immunologique des Leucémies). CD180 expression in B-cell lymphomas: A multicenter GEIL study. Cytometry B Clin Cytom. 2016 Sep;90(5):462-6. doi: 10.1002/cyto.b.21325. Epub 2015 Oct 6. PMID: 26384474.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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