Name : Human CD39/ENTPD1 Protein
Product Source :
Recombinant Human CD39/ENTPD1 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Thr38-Val478.[Accession | P49961-1]
Molecular Weight :
The protein has a predicted MW of 51.91 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in 20mM Tris, 150mM NaCL (pH 8.0).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CD39 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CD39 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human CD39, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-CD39 Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. Bioactivity Data Measured by its ability to hydrolyze the 5′-phosphate groups from the substrate adenosine-5′-triphosphate (ATP). The specific activity is >9000 pmol/min/µg.
Background :
CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues.CD39 is involved in the processes of thromboregulation and vascular inflammation. The administration of soluble NTPDase-1 may have therapeutic applications for the treatment of some vascular and transplantation-associated diseases .
Synonyms :
CD39; NTPD1; NTPDase 1; ADPase; ATPDase; DKFZp686D194; DKFZp686I093; EC 3.6.1; ENTPD1; FLJ40921; FLJ40959; SPG64
References & Citations :
(1)Häusler SF, Del Barrio I M , Diessner J , et al. Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion.[J]. Am J Transl Res, 2014, 6(2):129-139.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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