Name : Human CD52 Protein
Product Source :
Recombinant Human CD52 Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus. It contains Gly25-Ser36.[Accession | P31358]
Molecular Weight :
The protein has a predicted MW of 27.6 kDa. Due to glycosylation, the protein migrates to 38-48 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CD52 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%. SEC-HPLC The purity of Human CD52 is greater than 95% as determined by SEC-HPLC.
Background :
CD52, also known as CAMPATH-1 antigen, HE5, and gp20, is a cell surface glycoprotein that can be targeted to induce immune suppression by complement-mediated cell lysis. Mature human CD52 is a 12 amino acid peptide that is tethered to the cell surface with a GPI linkage.CD52 may play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Synonyms :
CD52 molecule; CD52; CDW52 antigen (CAMPATH-1 antigen); CDw52; He5; HEL-S-171mP; CAMPATH-1; CAMPATH1
References & Citations :
(1)Jiang L , Yuan C M , Hubacheck J , et al. Variable CD52 Expression in Mature T Cell and NK Cell Malignancies: Implications for Alemtuzumab Therapy[J]. British Journal of Haematology, 2009, 145(2):173-179.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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