Name : Mouse CD5L Protein
Product Source :
Recombinant Mouse CD5L Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Glu22-Val352.[Accession | Q9QWK4]
Molecular Weight :
The protein has a predicted MW of 37.7 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse CD5L on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse CD5L is greater than 95% as determined by SEC-HPLC.
Background :
CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a PRR of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes, such as infection, atherosclerosis, and cancer.
Synonyms :
CD5 antigen-like; CT-2; SP-alpha; API6; AIM; PRO229; SP-ALPHA; Spalpha; CD5L
References & Citations :
(1) Sanjurjo L, Aran G, Roher N, Valledor AF, Sarrias MR. AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease. J Leukoc Biol. 2015 Aug;98(2):173-84. doi: 10.1189/jlb.3RU0215-074R. Epub 2015 Jun 5. PMID: 26048980.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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