Name : Human ALK-7 Protein
Product Source :
Recombinant Human ALK-7 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Glu21-Glu113.[Accession | Q8NER5-1]
Molecular Weight :
The protein has a predicted MW of 11.11 kDa. Due to glycosylation, the protein migrates to 20-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in 20mM Tris, 150mM NaCl (pH 7.5).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ALK-7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human ALK-7 is greater than 95% as determined by SEC-HPLC.
Background :
Arterial stiffness is an important feature of diabetic macrovascular complications. Activin receptor-like kinase 7 (ALK7), a member of type I transforming growth factor-β (TGF-β) receptors, is correlated with pathogenic risks of type 2 diabetes mellitus and cardiovascular diseases and may be involved in cardiovascular remodeling.
Synonyms :
ACTR-IC; ACVR1C; ALK7
References & Citations :
Li WB, Zhao J, Liu L, Wang ZH, Han L, Zhong M, Zhang Y, Zhang W, Tang MX. Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats. Acta Diabetol. 2015 Aug;52(4):717-26. doi: 10.1007/s00592-014-0706-8. Epub 2015 Jan 11. PMID: 25577243.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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