Name : Human CD84/SLAMF5 Protein
Product Source :
Recombinant Human CD84/SLAMF5 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Lys22-Gly225.[Accession | Q9UIB8-1]
Molecular Weight :
The protein has a predicted MW of 25.4 kDa. Due to glycosylation, the protein migrates to 40-55 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CD84 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CD84 is greater than 95% as determined by SEC-HPLC.
Background :
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells.
Synonyms :
Hly9-beta; CD84; SLAMF5; LY9B; CD84 molecule; DKFZp781E2378;Hly9-β
References & Citations :
(1) Binsky-Ehrenreich I, Marom A, Sobotta MC, Shvidel L, Berrebi A, Hazan-Halevy I, Kay S, Aloshin A, Sagi I, Goldenberg DM, Leng L, Bucala R, Herishanu Y, Haran M, Shachar I. CD84 is a survival receptor for CLL cells. Oncogene. 2014 Feb 20;33(8):1006-16. doi: 10.1038/onc.2013.31. Epub 2013 Feb 25. PMID: 23435417; PMCID: PMC3796123.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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