Name : Human AMHRII Protein
Product Source :
Recombinant Human AMHRII Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Pro18-Ser144.[Accession | Q16671-1]
Molecular Weight :
The protein has a predicted MW of 40.2 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human AMHRII on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human AMHRII is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human AMHRII, hFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-AMHRII Antibody, hFc Tag with the EC50 of 86.4ng/ml determined by ELISA.
Background :
The aim of the current study was to explore whether anti-Müllerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women undergoing medically assisted reproduction. Three hundred in vitro fertilization or intracytoplasmic sperm injection patients constituted the study population, while 300 women with at least one spontaneous pregnancy participated as controls.
Synonyms :
MIS type II receptor; MISRII; MRII; AMHR; MISR2; AMHR2; AMH type II receptor; AMHR2; AMHRII; C14
References & Citations :
(1) Lazaros L, Fotaki A, Pamporaki C, Hatzi E, Kitsou C, Zikopoulos A, Virgiliou C, Kosmas I, Bouba I, Stefos T, Theodoridis G, Georgiou I. The ovarian response to standard gonadotropin stimulation is influenced by AMHRII genotypes. Gynecol Endocrinol. 2016 Aug;32(8):641-645. doi: 10.3109/09513590.2016.1149810. Epub 2016 Mar 2. PMID: 26933946.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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