Name : Human CDH16/Cadherin 16 Protein
Product Source :
Recombinant Human CDH16/Cadherin 16 Protein is expressed from HEK293 with His tag at the N-terminus. It contains Lys19-Ala786.[Accession | O75309-1]
Molecular Weight :
The protein has a predicted MW of MW 84.37 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in 50mM Tris, 100mM NaCl (pH 8.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CDH16 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CDH16 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human CDH16, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-CDH16 Antibody, Mouse IgG Tag with the EC50 of 7.5ng/ml determined by ELISA.
Background :
Cadherin (CDH)16/kidney-specific-cadherin was first described as a kidney-specific adhesion molecule and thereafter found expressed also in the thyroid gland. CDH16 is a thyroid-selective and hormone-dependent adhesion protein that might play a role during thyroid development and that may be a useful marker to monitor thyroid carcinomas.
Synonyms :
Cadherin-16; CDH16; Ksp-cadherin
References & Citations :
Calì G, Gentile F, Mogavero S, Pallante P, Nitsch R, Ciancia G, Ferraro A, Fusco A, Nitsch L. CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas. Endocrinology. 2012 Jan;153(1):522-34. doi: 10.1210/en.2011-1572. Epub 2011 Oct 25. PMID: 22028439.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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