Name : FITC-Labeled Human CLEC12A/MICL/CLL-1 Protein
Product Source :
Recombinant FITC-Labeled Human CLEC12A/MICL/CLL-1 Protein is expressed from HEK293 with His tag at the N-Terminus. It contains His65-Ala265.[Accession | Q5QGZ9-2]
Molecular Weight :
The protein has a predicted MW of 24.6 kDa. Due to glycosylation, the protein migrates to 35-55 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE FITC-Labeled Human CLEC12A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of FITC-Labeled Human CLEC12A is greater than 95% as determined by SEC-HPLC.
Background :
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML.
Synonyms :
MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2
References & Citations :
(1)Bill M, Aggerholm A, Kjeldsen E, Roug AS, Hokland P, Nederby L. Revisiting CLEC12A as leukaemic stem cell marker in AML: highlighting the necessity of precision diagnostics in patients eligible for targeted therapy. Br J Haematol. 2019 Mar;184(5):769-781. doi: 10.1111/bjh.15711. Epub 2018 Dec 5. PMID: 30520015.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
IFN-gamma ProteinSpecies
RBP4 ProteinAccession
Popular categories:
Ubiquitin-Specific Protease 7
IFN-delta