Name : Human CLEC7A Protein
Product Source :
Recombinant Human CLEC7A Protein is expressed from HEK293 with hFc tag at the N-Terminus. It contains Thr66-Met201.[Accession | Q9BXN2-2]
Molecular Weight :
The protein has a predicted MW of 41.79 kDa. Due to glycosylation, the protein migrates to 45-50 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CLEC7A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CLEC7A is greater than 95% as determined by SEC-HPLC.
Background :
Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). Dectin-1 signaling axis has been suggested to be targeted as an effective therapeutic strategy for cancers. Dectin-1 has also been elucidated ascetically in the heart, respiratory, intestinal, neurological and developmental disorders.
Synonyms :
Beta-glucan receptor; DC-associated C-type lectin 1; Dectin-1; Dectin1; CD369; BGR; CLECSF12; DECTIN1; CANDF4
References & Citations :
Kalia N, Singh J, Kaur M. The role of Dectin-1 in health and disease. Immunobiology. 2021 Mar;226(2):152071. doi: 10.1016/j.imbio.2021.152071. Epub 2021 Feb 5. PMID: 33588306.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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