Name : Human ANGPTL7/CDT6 Protein
Product Source :
Recombinant Human ANGPTL7/CDT6 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains GIn27-Pro346.[Accession | O43827]
Molecular Weight :
The protein has a predicted MW of 63.8 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ANGPTL7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Angiopoietin-like 7 (ANGPTL7), also known as Corneal-Derived Transcript 6 (CDT6), is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Its production is up‑regulated in trabecular meshwork cells by glucocorticoids and TGF-beta and in cartilage by TNF-alpha.
Synonyms :
angiopoietin-like 7; Angiopoietin-like factor; ANGPTL7; AngX; CDT6
References & Citations :
(1)Núria Comes, Buie L K K , Teresa Borrás. Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma[J]. Genes to cells : devoted to molecular & cellular mechanisms, 2011, 16(2):243-259.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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