Name : Cynomolgus CSPG4/MCSP Protein
Product Source :
Recombinant Cynomolgus CSPG4/MCSP Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ser1581-Ser2222.[Accession | A0A2K5UW71]
Molecular Weight :
The protein has a predicted MW of 69.30 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus CSPG4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Cynomolgus CSPG4 is greater than 95% as determined by SEC-HPLC.
Background :
The chondroitin sulfate proteoglycan-4 (CSPG4) is a cell surface proteoglycan overexpressed in a huge range of human and canine neoplastic lesions by tumor cells, tumor microenvironment and cancer initiating cells. CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization.
Synonyms :
CSPG4; MCSP; MCSPG; NG2
References & Citations :
Rolih V, Barutello G, Iussich S, De Maria R, Quaglino E, Buracco P, Cavallo F, Riccardo F. CSPG4: a prototype oncoantigen for translational immunotherapy studies. J Transl Med. 2017 Jul 1;15(1):151. doi: 10.1186/s12967-017-1250-4. PMID: 28668095; PMCID: PMC5494135.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
Basigin/CD147 ProteinSource
Elafin/Trappin-2 ProteinMolecular Weight
Popular categories:
Selectin
DDR1