Name : Biotinylated Mouse CX3CL1/Fractalkine Protein
Product Source :
Recombinant Biotinylated Mouse CX3CL1/Fractalkine Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Gln25-Thr336.[Accession | O35188]
Molecular Weight :
The protein has a predicted MW of 36 kDa. Due to glycosylation, the protein migrates to 70-83 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per ug by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Biotinylated Mouse CX3CL1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Biotinylated Mouse CX3CL1 is greater than 95% as determined by SEC-HPLC.
Background :
Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma.
Synonyms :
Fractalkine; Neurotactin; CX3CL1; Cx3c; Fkn; ABCD-3; C3Xkine; CXC3; CXC3C; NTN; NTT; SCYD1
References & Citations :
(1) Korbecki J, Simińska D, Kojder K, Grochans S, Gutowska I, Chlubek D, Baranowska-Bosiacka I. Fractalkine/CX3CL1 in Neoplastic Processes. Int J Mol Sci. 2020 May 25;21(10):3723. doi: 10.3390/ijms21103723. PMID: 32466280; PMCID: PMC7279446.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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