Name : Human CXCL4 Protein
Product Source :
Recombinant Human CXCL4 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Glu32-Ser101.[Accession | P02776]
Molecular Weight :
The protein has a predicted MW of 34.5 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CXCL4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CXCL4 is greater than 95% as determined by SEC-HPLC.
Background :
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes.
Synonyms :
PF-4; Oncostatin-A; CXCL4; SCYB4; Iroplact; MGC138298
References & Citations :
(1) Ruytinx P, Proost P, Struyf S. CXCL4 and CXCL4L1 in cancer. Cytokine. 2018 Sep;109:65-71. doi: 10.1016/j.cyto.2018.02.022. PMID: 29903575.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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