Name : Mouse DDR2 Protein
Product Source :
Recombinant Mouse DDR2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Lys22-Arg399.[Accession | Q62371]
Molecular Weight :
The protein has a predicted MW of 43.72 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse DDR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse DDR2 is greater than 95% as determined by SEC-HPLC.
Background :
Discoidin domain receptor (DDR) 2 is a collagen receptor that is implicated in several cancer types including breast and prostate cancers. DDR2 might be closely associated with ovarian cancer progression and metastasis. Its high expression may serve as a potential prognostic biomarker in human ovarian cancer.
Synonyms :
Discoidin domain receptor 2; CD167b; Ntrkr3; Tkt; Tyro10; AW495251; TKTMIG20a;
References & Citations :
(1) Poudel B, Lee YM, Kim DK. DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway. Acta Biochim Biophys Sin (Shanghai). 2015 Apr;47(4):292-8. doi: 10.1093/abbs/gmv005. Epub 2015 Mar 1. PMID: 25733533.(2) Fan Y, Xu Z, Fan J, Huang L, Ye M, Shi K, Huang Z, Liu Y, He L, Huang J, Wang Y, Li Q. Prognostic significance of discoidin domain receptor 2 (DDR2) expression in ovarian cancer. Am J Transl Res. 2016 Jun 15;8(6):2845-50. PMID: 27398168; PMCID: PMC4931179.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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