Name : Human ANTXR2 Protein
Product Source :
Recombinant Human ANTXR2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gln34-Gly318.[Accession | NP_477520.2]
Molecular Weight :
The protein has a predicted MW of 31.81 kDa. Due to glycosylation, the protein migrates to 38-43 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ANTXR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human ANTXR2 is greater than 95% as determined by SEC-HPLC.
Background :
The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultured in vitro. ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
Synonyms :
Antxr2; HFS; cI-35; CMG-2; CMG2; ISH; JHF; JHS
References & Citations :
Reeves CV, Dufraine J, Young JA, Kitajewski J. Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis. Oncogene. 2010 Feb 11;29(6):789-801. doi: 10.1038/onc.2009.383. Epub 2009 Nov 9. PMID: 19901963; PMCID: PMC2939496.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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