Name : Human EphA2 Protein
Product Source :
Recombinant Human EphA2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala24-Val537.[Accession | P29317-1]
Molecular Weight :
The protein has a predicted MW of 57.56 kDa. Due to glycosylation, the protein migrates to 58-65 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human EphA2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human EphA2 is greater than 95% as determined by SEC-HPLC.
Background :
Erythropoietin-producing hepatocellular receptor A2 (EphA2) receptor tyrosine kinase plays an important role in tissue organization and homeostasis in normal organs. EphA2 is overexpressed in a variety of types of solid tumours with oncogenic functions.
Synonyms :
Ephrin type-A receptor 2; Epithelial cell kinase; ECK; MPK-5; MPK5; SEK-2; SEK2; Myk2; AW54528
References & Citations :
Huang C, Chen Z, He Y, He Z, Ban Z, Zhu Y, Ding L, Yang C, Jeong JH, Yuan W, Yang L. EphA2 promotes tumorigenicity of cervical cancer by up-regulating CDK6. J Cell Mol Med. 2021 Mar;25(6):2967-2975. doi: 10.1111/jcmm.16337. Epub 2021 Feb 14. PMID: 33586348; PMCID: PMC7957165.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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