Name : Human EMMPRIN/CD147 Protein
Product Source :
Recombinant Human EMMPRIN/CD147 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala22-His205.[Accession | NP_940991.1]
Molecular Weight :
The protein has a predicted MW of 21.2 kDa. Due to glycosylation, the protein migrates to 28-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human EMMPRIN on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human EMMPRIN is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human EMMPRIN, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-EMMPRIN Antibody, hFc Tag with the EC50 of 8.4ng/ml determined by ELISA.
Background :
CD147, also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or basigin, is expressed in a variety of cell types. It is involved in the regulation of extracellular matrix (ECM) remodeling during physiological and pathological processes including wound healing, inflammatory diseases, and cancer. CD147 is a diagnostic and therapeutic target in cancer and inflammatory diseases, either directly or indirectly, by targeting CD147 partners.
Synonyms :
Basigin; BSG; CD147; 5F7; M6; OK; TCSF
References & Citations :
(1) Guindolet D, Gabison EE. Role of CD147 (EMMPRIN/Basigin) in Tissue Remodeling. Anat Rec (Hoboken). 2020 Jun;303(6):1584-1589. doi: 10.1002/ar.24089. Epub 2019 Mar 15. PMID: 30768865.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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