Product Name :
Parsaclisib (INCB050465) Hydrochloride
Description:
Parsaclisib (INCB050465, IBI376) Hydrochloride is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
CAS:
1995889-48-9
Molecular Weight:
432.88
Formula:
C20H22ClFN6O2
Chemical Name:
4-[3-(1-4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-ylethyl)-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one
Smiles :
CC1=NN(C(C)C2=CC(Cl)=C(F)C(C3CNC(=O)C3)=C2OCC)C2=NC=NC(N)=C12
InChiKey:
ZQPDJCIXJHUERQ-UHFFFAOYSA-N
InChi :
InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Calcitriol Protocol
Shelf Life:
≥12 months if stored properly.Erythrosine B Fluorescent Dye
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32938710
Additional information:
Parsaclisib (INCB050465, IBI376) Hydrochloride is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.|Product information|CAS Number: 1995889-48-9|Molecular Weight: 432.88|Formula: C20H22ClFN6O2|Chemical Name: 4-[3-(1-4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-ylethyl)-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one|Smiles: CC1=NN(C(C)C2=CC(Cl)=C(F)C(C3CNC(=O)C3)=C2OCC)C2=NC=NC(N)=C12|InChiKey: ZQPDJCIXJHUERQ-UHFFFAOYSA-N|InChi: InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C). DMSO: 94 mg/mL(200.28 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|