Product Name :
Pavinetant
Description:
Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.
CAS:
941690-55-7
Molecular Weight:
459.56
Formula:
C26H25N3O3S
Chemical Name:
3-methanesulfonamido-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
Smiles :
CS(=O)(=O)NC1C(=C2C=CC=CC2=NC=1C1=CC=CC=C1)C(=O)N[C@@H](CC)C1=CC=CC=C1
InChiKey:
QYTBBBAHNIWFOD-NRFANRHFSA-N
InChi :
InChI=1S/C26H25N3O3S/c1-3-21(18-12-6-4-7-13-18)28-26(30)23-20-16-10-11-17-22(20)27-24(19-14-8-5-9-15-19)25(23)29-33(2,31)32/h4-17,21,29H,3H2,1-2H3,(H,28,30)/t21-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.|Product information|CAS Number: 941690-55-7|Molecular Weight: 459.56|Formula: C26H25N3O3S|Chemical Name: 3-methanesulfonamido-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide|Smiles: CS(=O)(=O)NC1C(=C2C=CC=CC2=NC=1C1=CC=CC=C1)C(=O)N[C@@H](CC)C1=CC=CC=C1|InChiKey: QYTBBBAHNIWFOD-NRFANRHFSA-N|InChi: InChI=1S/C26H25N3O3S/c1-3-21(18-12-6-4-7-13-18)28-26(30)23-20-16-10-11-17-22(20)27-24(19-14-8-5-9-15-19)25(23)29-33(2,31)32/h4-17,21,29H,3H2,1-2H3,(H,28,30)/t21-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 50 mg/mL (108.80 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.E1210 Anti-infection |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Pavinetant (AZD2624) is a potent and selective NK3 receptor antagonist which is developed for the treatment of schizophrenia.Dasatinib custom synthesis Pavinetant exhibits an inhibitory effect on microsomal CYP3A4/5 activities with apparent IC50 values of 7.PMID:32703086 1 and 19.8 μM for midazolam and testosterone assays, respectively. No time-dependent inactivation of CYP3A4/5 activity by Pavinetant is observed. Pavinetant demonstrates weak to no inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2D6.|Products are for research use only. Not for human use.|