Ur individuals ahead of and just after surgery, Table S1: Demographic and pathological Information and facts, Table S2: MRI scans and neuropsychological assessments completed by every single participant. Author Contributions: Conceptualisation, R.R.-G., M.G.H., G.A.A.B., S.J.P., T.S., Y.E. and J.S.; methodology, software program, validation, formal evaluation, R.R.-G., M.G.H., R.A.I.B., A.M., M.A., J.M.G., T.S., Y.E. and J.S.; investigation, resources, R.R.-G., M.G.H., R.A.I.B., A.M., M.A., B.C.-F., J.M.G., G.A.A.B., S.J.P., T.S., Y.E. and J.S.; data curation, R.R.-G., M.G.H. and J.S.; writing review and editing, visualisation, R.R.-G., M.G.H., R.A.I.B., A.M., M.A., B.C.-F., J.M.G., G.A.A.B., S.J.P., T.S., Y.E. and J.S.; supervision, project administration, funding acquisition, R.R.-G., M.G.H., T.S., Y.E. and J.S. All authors have study and agreed to the published version of the manuscript. Funding: This investigation was supported by the Guarantors of Brain, Cancer Research UK Cambridge Centre, The Brain Tumour Charity and also the EMERGIA Junta de Andalucia system. Y.E. is funded by a Royal Society Dorothy Hodgkin Investigation Fellowship (DHF130100). JMG is funded by the Ministerio de Ciencia e Innovaci (Espa )/FEDER beneath the RTI2018-098913-B100 project, by the Consejer de Econom , Innovaci , Ciencia y Empleo (Junta de Andaluc ) and FEDER below CV20-45250, A-TIC-080-UGR18, B-TIC-586-UGR20 and P20-00525 projects. MA was funded by a Cambridge Trust–Yousef Jameel Scholarship. This investigation was also supported by the NIHR Cambridge Biomedical Study Centre (BRC-1215-20014). SJP (NIHR Profession Improvement Fellowship, CDF2018-11-ST2-003) is funded by the National Institute for Wellness Investigation (NIHR) for this analysis project. The views expressed are these from the author(s) and not necessarily these of your NIHR or the Division of Health and Social Care. Institutional Review Board Statement: The study was performed as outlined by the recommendations on the Declaration of Helsinki and approved by the Cambridge Central Analysis Ethics Committee (Reference quantity 16/EE/0151). Informed Sapanisertib site consent Statement: Informed consent was obtained from all subjects involved in the study. Data Availability Statement: In accordance with ethics specifications, information are going to be created obtainable to collaborating centres upon request. Acknowledgments: The authors thank all individuals for their generous involvement in the study. We also thank Mallory Owen, Emma Woodberry, Rohitashwa Sinha, Pedro Coelho, Jessica Ingham, Alexa Mcdonald and Luca Villa for their Diminazene custom synthesis contribution towards the study. Conflicts of Interest: The authors report no competing interests.AbbreviationsGS = worldwide signal; BOLD = blood oxygenation level-dependent; MDT = neuro-oncology multidisciplinary group; FD = framewise displacement; HCs = wholesome controls; AMIPB = Adult Memory and Information Processing Battery Task; BIMPB = Brain Injury Rehabilitation Trust Memory and Info Processing Battery; WAIS = Wechsler Adult Intelligence Scale.
cancersArticleTBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3pGirijesh Kumar Patel 1 , Sayanika Dutta 1 , Mosharaf Mahmud Syed 1 , Sabarish Ramachandran 1 , Monica Sharma 2 , Venkatesh Rajamanickam 3 , Vadivel Ganapathy 1 , David J. DeGraff four , Kevin Pruitt 2 , Manisha Tripathi 1,five, and Srinivas Nandana 1,five, Division of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; [email protected] (G.K.P.); [email protected] (S.D.